abstract：:Osteoblasts and adipocytes are differentiated from common mesenchymal stem cells (MSCs) in processes which are tightly controlled by various growth factors, signaling molecules, transcriptional factors and microRNAs. Recently, chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) was identified as a ...

journal_title：Cell death & disease

authors： Jeong BC,Kang IH,Hwang YC,Kim SH,Koh JT

更新日期：2014-11-20 00:00:00

abstract：:The oncogenic human papillomavirus (HPV) E6/E7 proteins are essential for the onset and maintenance of HPV-associated malignancies. Here, we report that activation of the cellular ubiquitin-proteasome system (UPS) by the omega-3 fatty acid, docosahexaenoic acid (DHA), leads to proteasome-mediated degradation of E6/E7 ...

journal_title：Cell death & disease

authors： Jing K,Shin S,Jeong S,Kim S,Song KS,Park JH,Heo JY,Seo KS,Park SK,Kweon GR,Wu T,Park JI,Lim K

更新日期：2014-11-13 00:00:00

abstract：:Mitochondrial biogenesis and mitophagy are recognized as critical processes underlying mitochondrial homeostasis. However, the molecular pathway(s) coordinating the balance between these cellular programs is still poorly investigated. Here, we show an induction of the nuclear and mitochondrial peroxisome proliferator-...

journal_title：Cell death & disease

authors： Baldelli S,Aquilano K,Ciriolo MR

更新日期：2014-11-06 00:00:00

abstract：:Glioma patients commonly suffer from epileptic seizures. However, the mechanisms of glioma-associated epilepsy are far to be completely understood. Using glioma-neurons co-cultures, we found that tumor cells are able to deeply influence neuronal chloride homeostasis, by depolarizing the reversal potential of γ-aminobu...

journal_title：Cell death & disease

authors： Di Angelantonio S,Murana E,Cocco S,Scala F,Bertollini C,Molinari MG,Lauro C,Bregestovski P,Limatola C,Ragozzino D

更新日期：2014-10-30 00:00:00

abstract：:Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 and suppresses gene expression by catalyzing histone H3 methylation on lysine 27. EZH2 is overexpressed in metastatic prostate cancer and has been shown to promote cell proliferation and metastasis. Here we show that EZH2 ...

journal_title：Cell death & disease

authors： Zhang Q,Padi SK,Tindall DJ,Guo B

更新日期：2014-10-23 00:00:00

abstract：:Malignant gliomas, the most common solid tumors in the central nervous system, are essentially incurable due to their rapid growth and very invasive nature. One potential approach to eradicating glioma cells is to force these cells to undergo terminal differentiation and, in the process, to irreversible postmitotic ar...

journal_title：Cell death & disease

authors： Su Z,Zang T,Liu ML,Wang LL,Niu W,Zhang CL

更新日期：2014-10-16 00:00:00

abstract：:β-Catenin has been widely implicated in the regulation of mammalian development and cellular homeostasis. However, the mechanisms by which Wnt/β-catenin signaling components regulate physiological events during brain development remain undetermined. Inactivation of glycogen synthase kinase (GSK)-3β leads to β-catenin ...

journal_title：Cell death & disease

authors： Shin J,Shin Y,Oh SM,Yang H,Yu WJ,Lee JP,Huh SO,Lee SH,Suh YH,Chung S,Kim HS

更新日期：2014-10-16 00:00:00

abstract：:We sought to identify miRNAs that can efficiently induce apoptosis in ovarian cancer cells by overcoming BCL-X(L) and MCL1 anti-apoptotic activity, using combined computational and experimental approaches. We found that miR-491-5p efficiently induces apoptosis in IGROV1-R10 cells by directly inhibiting BCL-X(L) expres...

journal_title：Cell death & disease

authors： Denoyelle C,Lambert B,Meryet-Figuière M,Vigneron N,Brotin E,Lecerf C,Abeilard E,Giffard F,Louis MH,Gauduchon P,Juin P,Poulain L

更新日期：2014-10-09 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest malignancies with an overall life expectancy of 6 months despite current therapies. NF-κB signalling has been shown to be critical for this profound cell-autonomous resistance against chemotherapeutic drugs and death receptor-induced apoptosis, bu...

journal_title：Cell death & disease

authors： Geismann C,Grohmann F,Sebens S,Wirths G,Dreher A,Häsler R,Rosenstiel P,Hauser C,Egberts JH,Trauzold A,Schneider G,Sipos B,Zeissig S,Schreiber S,Schäfer H,Arlt A

更新日期：2014-10-09 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) can be divided into groups based on biomarkers of poor prognosis. The expression of the tyrosine kinase ZAP-70 (member of the Syk tyrosine kinase family) in CLL cells is associated with shorter overall survival in CLL patients. Currently, there is a lack of targeted therapies for pat...

journal_title：Cell death & disease

authors： Dielschneider RF,Xiao W,Yoon JY,Noh E,Banerji V,Li H,Marshall AJ,Johnston JB,Gibson SB

更新日期：2014-10-02 00:00:00

abstract：:MEIS2 has an important role in development and organogenesis, and is implicated in the pathogenesis of human cancer. The molecular basis of MEIS2 action in tumorigenesis is not clear. Here, we show that MEIS2 is highly expressed in human neuroblastoma cell lines and is required for neuroblastoma cell survival and prol...

journal_title：Cell death & disease

authors： Zha Y,Xia Y,Ding J,Choi JH,Yang L,Dong Z,Yan C,Huang S,Ding HF

更新日期：2014-09-11 00:00:00

abstract：:Adenanthin, a natural diterpenoid isolated from the leaves of Isodon adenanthus, has recently been reported to induce leukemic cell differentiation by targeting peroxiredoxins (Prx) I and II. On the other hand, increasing lines of evidence propose that these Prx proteins would become potential targets to screen drugs ...

journal_title：Cell death & disease

authors： Hou JK,Huang Y,He W,Yan ZW,Fan L,Liu MH,Xiao WL,Sun HD,Chen GQ

更新日期：2014-09-04 00:00:00

abstract：:Redox imbalance generates multiple cellular damages leading to oxidative stress-mediated pathological conditions such as neurodegenerative diseases and cancer progression. Therefore, maintenance of reactive oxygen species (ROS) homeostasis is most important that involves well-defined antioxidant machinery. In the pres...

journal_title：Cell death & disease

authors： Srivastava S,Sinha D,Saha PP,Marthala H,D'Silva P

更新日期：2014-08-28 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are a heterogeneous population of cells that proliferate in vitro as plastic-adherent cells, have a fibroblast-like morphology, form colonies in vitro and can differentiate into bone, cartilage and fat cells. The abundance, ease and repeatable access to subcutaneous adipose tissue and the...

journal_title：Cell death & disease

authors： Kim JY,Shin KK,Lee AL,Kim YS,Park HJ,Park YK,Bae YC,Jung JS

更新日期：2014-08-21 00:00:00

abstract：:Histones and their post-translational modifications have key roles in chromatin remodeling and gene transcription. Besides intranuclear functions, histones act as damage-associated molecular pattern molecules when they are released into the extracellular space. Administration of exogenous histones to animals leads to ...

journal_title：Cell death & disease

authors： Chen R,Kang R,Fan XG,Tang D

更新日期：2014-08-14 00:00:00

abstract：:MicroRNAs (miRs) are small noncoding RNAs that negatively regulate gene expression by binding to the three untranslated regions of their target mRNAs. Deregulations of miRs were shown to play pivotal roles in tumorigenesis and progression. Recent research efforts have been devoted to translating these basic discoverie...

journal_title：Cell death & disease

authors： Li XJ,Ren ZJ,Tang JH

更新日期：2014-07-17 00:00:00

abstract：:The control of glucose metabolism and the cell cycle must be coordinated in order to guarantee sufficient ATP and anabolic substrates at distinct phases of the cell cycle. The family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) are well established regulators of glucose metabolism via their synt...

journal_title：Cell death & disease

authors： Yalcin A,Clem BF,Imbert-Fernandez Y,Ozcan SC,Peker S,O'Neal J,Klarer AC,Clem AL,Telang S,Chesney J

更新日期：2014-07-17 00:00:00

abstract：:Previous studies have shown that miR-203 is a skin-specific microRNA (miRNA) with a profound role in skin cell differentiation. However, emerging microarray and deep sequencing data revealed that miR-203 is also expressed in embryonic skeletal muscle and myoblasts. In this study, we found that miR-203 was transiently ...

journal_title：Cell death & disease

authors： Luo W,Wu H,Ye Y,Li Z,Hao S,Kong L,Zheng X,Lin S,Nie Q,Zhang X

更新日期：2014-07-17 00:00:00

abstract：:Recent evidence indicates that long noncoding RNAs (lncRNAs) have a critical role in the regulation of cellular processes such as differentiation, proliferation, and metastasis. These lncRNAs are dysregulated in a variety of cancers and many function as tumor suppressors; however, the regulatory factors involved in si...

journal_title：Cell death & disease

authors： Sun M,Liu XH,Lu KH,Nie FQ,Xia R,Kong R,Yang JS,Xu TP,Liu YW,Zou YF,Lu BB,Yin R,Zhang EB,Xu L,De W,Wang ZX

更新日期：2014-06-26 00:00:00

abstract：:Chronic psychological stress has been demonstrated to play an important role in several severe diseases, but whether it affects disease therapy or not remains unclear. Mesenchymal stem cells (MSCs) have been demonstrated to have therapeutic potentials in treating tissue injury based on their multidifferentiation poten...

journal_title：Cell death & disease

authors： Yang X,Han ZP,Zhang SS,Zhu PX,Hao C,Fan TT,Yang Y,Li L,Shi YF,Wei LX

更新日期：2014-06-26 00:00:00

abstract：:Reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress are paradoxically implicated in myocardial ischemia/reperfusion (I/R) injury and cardioprotection. However, the precise interpretation for the dual roles of ROS and its relationship with the ER stress during I/R remain elusive. Here we investigated th...

journal_title：Cell death & disease

authors： Wang ZH,Liu JL,Wu L,Yu Z,Yang HT

更新日期：2014-06-19 00:00:00

abstract：:Acute lung injury (ALI) is characterized by pulmonary endothelial and epithelial cell damage, and loss of the alveolar-capillary barrier. We have previously shown that P2X7 receptor (P2X7R), a cell death receptor, is specifically expressed in alveolar epithelial type I cells (AEC I). In this study, we hypothesized tha...

journal_title：Cell death & disease

authors： Guo Y,Mishra A,Weng T,Chintagari NR,Wang Y,Zhao C,Huang C,Liu L

更新日期：2014-06-12 00:00:00

abstract：:Diffusely infiltrating gliomas are among the most prognostically discouraging neoplasia in human. Temozolomide (TMZ) in combination with radiotherapy is currently used for the treatment of glioblastoma (GBM) patients, but less than half of the patients respond to therapy and chemoresistance develops rapidly. Epigeneti...

journal_title：Cell death & disease

authors： Haemmig S,Baumgartner U,Glück A,Zbinden S,Tschan MP,Kappeler A,Mariani L,Vajtai I,Vassella E

更新日期：2014-06-05 00:00:00

abstract：:Our understanding of the mitochondrial or intrinsic apoptosis pathway and its role in chemotherapy resistance has increased significantly in recent years by a combination of experimental studies and mathematical modelling. This combined approach enhanced the quantitative and kinetic understanding of apoptosis signal t...

journal_title：Cell death & disease

authors： Würstle ML,Zink E,Prehn JH,Rehm M

更新日期：2014-05-29 00:00:00

abstract：:Cockayne syndrome (CS) is a progressive developmental and neurodegenerative disorder resulting in premature death at childhood and cells derived from CS patients display DNA repair and transcriptional defects. CS is caused by mutations in csa and csb genes, and patients with csb mutation are more prevalent. A hallmark...

journal_title：Cell death & disease

authors： Ciaffardini F,Nicolai S,Caputo M,Canu G,Paccosi E,Costantino M,Frontini M,Balajee AS,Proietti-De-Santis L

更新日期：2014-05-29 00:00:00

abstract：:Estrogen receptor-alpha positive (ER(+)) breast cancers comprise the majority of human breast cancers, but molecular mechanisms underlying this subtype of breast cancers remain poorly understood. Here, we show that ER(+) mammary luminal tumors arising in Tip30(-/-)MMTV-Neu mice exhibited increased enrichment of lumina...

journal_title：Cell death & disease

authors： Chen F,Li A,Gao S,Hollern D,Williams M,Liu F,VanSickle EA,Andrechek E,Zhang C,Yang C,Luo R,Xiao H

更新日期：2014-05-22 00:00:00

abstract：:Hepatocyte transplantation as a substitute strategy of orthotopic liver transplantation is being studied for treating end-stage liver diseases. Several technical hurdles must be overcome in order to achieve the therapeutic liver repopulation, such as the problem of insufficient expansion of the transplanted hepatocyte...

journal_title：Cell death & disease

authors： Xiang D,Liu CC,Wang MJ,Li JX,Chen F,Yao H,Yu B,Lu L,Borjigin U,Chen YX,Zhong L,Wangensteen KJ,He ZY,Wang X,Hu YP

更新日期：2014-05-22 00:00:00

abstract：:Intestinal epithelial cells (IECs) not only have a critical function in the absorption of nutrients, but also act as a physical barrier between our body and the outside world. Damage and death of the epithelial cells lead to the breakdown of this barrier function and inflammation due to access of the immune system to ...

journal_title：Cell death & disease

authors： Grabinger T,Luks L,Kostadinova F,Zimberlin C,Medema JP,Leist M,Brunner T

更新日期：2014-05-15 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is involved in insulin resistance (IR) and diabetic retinopathy. In retinal pigment epithelial (RPE) cells, insulin activates the mTOR pathway, inducing hypoxia-inducible factor-1α (HIF-1α) and HIF-dependent transcription in serum-free minimum essential medium Eagle (MEM). Serendip...

journal_title：Cell death & disease

authors： Leontieva OV,Demidenko ZN,Blagosklonny MV

更新日期：2014-05-08 00:00:00

abstract：:The growing number of studies suggested that inhibition of autophagy enhances the efficacy of Akt kinase inhibitors in cancer therapy. Here, we provide evidence that ML-9, a widely used inhibitor of Akt kinase, myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1), represents the 'two-in-one' com...

journal_title：Cell death & disease

authors： Kondratskyi A,Yassine M,Slomianny C,Kondratska K,Gordienko D,Dewailly E,Lehen'kyi V,Skryma R,Prevarskaya N

更新日期：2014-04-24 00:00:00

abstract：:Met, the tyrosine kinase receptor for hepatocyte growth factor (HGF), mainly activates prosurvival pathways, including protection from apoptosis. In this work, we investigated the cardioprotective mechanisms of Met activation by agonist monoclonal antibodies (mAbs). Cobalt chloride (CoCl2), a chemical mimetic of hypox...

journal_title：Cell death & disease

authors： Gallo S,Gatti S,Sala V,Albano R,Costelli P,Casanova E,Comoglio PM,Crepaldi T

更新日期：2014-04-17 00:00:00

abstract：:It is largely recognized that fibroblast activation protein (FAP) is expressed in cancer-associated fibroblasts (CAFs) of many human carcinomas. Furthermore, FAP was recently also reported to be expressed in carcinoma cells of the breast, stomach, pancreatic ductal adenocarcinoma, colorectum, and uterine cervix. The c...

journal_title：Cell death & disease

authors： Wang H,Wu Q,Liu Z,Luo X,Fan Y,Liu Y,Zhang Y,Hua S,Fu Q,Zhao M,Chen Y,Fang W,Lv X

更新日期：2014-04-10 00:00:00

abstract：:Hereditary pancreatitis (HP) is an autosomal dominant disease that displays the features of both acute and chronic pancreatitis. Mutations in human cationic trypsinogen (PRSS1) are associated with HP and have provided some insight into the pathogenesis of pancreatitis, but mechanisms responsible for the initiation of ...

journal_title：Cell death & disease

authors： Athwal T,Huang W,Mukherjee R,Latawiec D,Chvanov M,Clarke R,Smith K,Campbell F,Merriman C,Criddle D,Sutton R,Neoptolemos J,Vlatković N

更新日期：2014-04-10 00:00:00

abstract：:Functional neuronal circuits require a constant remodeling of their network composed of highly interconnected neurons. The plasticity of synapses and the shaping of elaborated dendritic branches are energy demanding and therefore depend on an efficient mitochondrial oxidative phosphorylation (OXPHOS). The spatial and ...

journal_title：Cell death & disease

authors： Gioran A,Nicotera P,Bano D

更新日期：2014-04-10 00:00:00

abstract：:While TRAIL is a promising anticancer agent due to its ability to selectively induce apoptosis in neoplastic cells, many tumors, including pancreatic ductal adenocarcinoma (PDA), display intrinsic resistance, highlighting the need for TRAIL-sensitizing agents. Here we report that TRAIL-induced apoptosis in PDA cell li...

journal_title：Cell death & disease

authors： Zhang JS,Herreros-Villanueva M,Koenig A,Deng Z,de Narvajas AA,Gomez TS,Meng X,Bujanda L,Ellenrieder V,Li XK,Kaufmann SH,Billadeau DD

更新日期：2014-03-27 00:00:00

abstract：:Inhibition of human mitochondrial peptide deformylase (HsPDF) depolarizes the mitochondrial membrane, reduces mitochondrial protein translation and causes apoptosis in Burkitt's lymphoma. We showed that HsPDF mRNA and protein levels were overexpressed in cancer cells and primary acute myeloid leukemia samples. Myc reg...

journal_title：Cell death & disease

authors： Sheth A,Escobar-Alvarez S,Gardner J,Ran L,Heaney ML,Scheinberg DA

更新日期：2014-03-27 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, and is also highly resistant to conventional chemotherapy treatments. In this study, we report that Longikaurin A (LK-A), an ent-kaurane diterpenoid isolated from the plant Isodon ternifolius, induced cell cycle arrest and apoptosis in hum...

journal_title：Cell death & disease

authors： Liao YJ,Bai HY,Li ZH,Zou J,Chen JW,Zheng F,Zhang JX,Mai SJ,Zeng MS,Sun HD,Pu JX,Xie D

更新日期：2014-03-20 00:00:00

abstract：:Phenothiazines are a family of heterocyclic compounds whose clinical utility includes treatment of psychiatric disorders as well as chemotherapy-induced emesis. Various studies have demonstrated that these compounds possess cytotoxic activities in tumor cell lines of different origin. However, there is considerable co...

journal_title：Cell death & disease

authors： Zong D,Zielinska-Chomej K,Juntti T,Mörk B,Lewensohn R,Hååg P,Viktorsson K

更新日期：2014-03-13 00:00:00

abstract：:Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of several toxic and damaging molecules. These are necessary to figh...

journal_title：Cell death & disease

authors： Cauwels A,Rogge E,Vandendriessche B,Shiva S,Brouckaert P

更新日期：2014-03-06 00:00:00

abstract：:Novel therapeutic targets are required to protect the heart against cell death from acute ischemia-reperfusion injury (IRI). Mutations in the DJ-1 (PARK7) gene in dopaminergic neurons induce mitochondrial dysfunction and a genetic form of Parkinson's disease. Genetic ablation of DJ-1 renders the brain more susceptible...

journal_title：Cell death & disease

authors： Dongworth RK,Mukherjee UA,Hall AR,Astin R,Ong SB,Yao Z,Dyson A,Szabadkai G,Davidson SM,Yellon DM,Hausenloy DJ

更新日期：2014-02-27 00:00:00